The reference site for Dolasetron

Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

WHAT IS Dolasetron?

Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy or surgery.

Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. However, it does not have much effect on vomiting due to motion sickness.

Furthermore, this drug does not have any effect on dopamine receptors or muscarinic receptors.

 

Brand Name(s): Anzemet
CAS nº: 115956-12-2
(dol a’ se tron)

 

Product Info

The sections below will provide you with more specific information and guidelines related to dolasetron and its correct use. Please read them carefully.

FDA Information

Dolasetron is FDA approved for the prevention of nausea and vomiting associated with some types of chemotherapy. It is also approved for the prevention and treatment of nausea and vomiting after surgery.

Why is this medication prescribed?

Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy or surgery.

Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata.

However, it does not have much effect on vomiting due to motion sickness, and has no effect on dopamine receptors or muscarinic receptors.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Dolasetron comes as a tablet to be take orally, and in an injectable form.

The first dose of dolasetron is usually taken in a hospital or clinic 30 minutes before chemotherapy is begun or 15 minutes before anesthesia is stopped.

Take dolasetron exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Dolasetron can be taken with or without food, and with a full glass of water.

The injectable form of dolasetron is intended for intravenous use. However, it can also be used orally when mixed with apple or apple-grape juice as directed by your doctor. The mixture of dolasetron and juice is good for up to 2 hours at room temperature.

What special precautions should I follow?

BEFORE TAKING DOLASETRON:

It is important to inform your doctor if you have low levels of potassium or magnesium in your blood, if you are taking a diuretic (water pill), have a history of congenital QT syndrome, or are taking a medicine to treat an irregular heartbeat. Dolasetron may affect your heart, especially if you have any of the conditions or are taking any of the medicines listed above.

Dolasetron is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take dolasetron without first talking to your doctor if you are pregnant or if you are planning a pregnancy.

Additionally, it is not known whether dolasetron passes into breast milk. Do not take dolasetron without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose.

Never take a double dose of this medication.

What side effects can this medication cause?

Possible side effects from dolasteron include:

headache
dizziness

Tell your doctor if any of these symptoms are severe or do not go away:

headache
fatigue, drowsiness, or dizziness
diarrhea

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives)
irregular heartbeats
muscle cramps or uncontrollable movements

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed, and talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call the local emergency services on 911.

Symptoms of a dolasetron overdose are not well known but might include:

tremors
seizures
heart problems

Product Images

PICTURES OF DOLASETRON MEDICATION

Below you will find images and specific information on the principal types of dolasetron that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: ANZEMET®
Strength(s): 50 MG
Imprint: ANZEMET 50
Manufacturer: AVENTIS PHARMACEUTICALS

Name: ANZEMET®
Strength(s): 100 MG
Imprint: ANZEMET
Manufacturer: AVENTIS PHARMACEUTICALS

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